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Description:Treatment for a cold sore is made based on the result of the diagnostic test done on the cold sore ? viral culture, viral DNA or Tzanck test. However, there are common cures for cold sore which help ease pain and gradually eradicate symptoms. These are antiviral medications, topical antiviral cream, and for severe cases, a physician?s intervention. Antiviral medications works best if taken when the virus is just starting to come